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詳しく知りたいのですね。


まずは、下記の論文とそれらに引用されている論文を読んでみましょう。
1: Related Articles, LinksSzymańska H.

[Genetically engineered mice: mouse models for cancer research]
Postepy Hig Med Dosw (Online). 2007 Oct 26;61:639-45. Review. Polish.
PMID: 17971765 [PubMed - indexed for MEDLINE]2: Related Articles, LinksChecler F, Sunyach C, Pardossi-Piquard R, Sévalle J, Vincent B, Kawarai T, Girardot N, St George-Hyslop P, da Costa CA.

The gamma/epsilon-secretase-derived APP intracellular domain fragments regulate p53.
Curr Alzheimer Res. 2007 Sep;4(4):423-6. Review.
PMID: 17908046 [PubMed - indexed for MEDLINE]3: Related Articles, LinksFriedman LM, Dror AA, Avraham KB.

Mouse models to study inner ear development and hereditary hearing loss.
Int J Dev Biol. 2007;51(6-7):609-31. Review.
PMID: 17891721 [PubMed - indexed for MEDLINE]4: Related ArticlesWintermantel TM, Elzer J, Herbison AE, Fritzemeier KH, Schütz G.

Genetic dissection of estrogen receptor signaling in vivo.
Ernst Schering Found Symp Proc. 2006;(1):25-44. Review.
PMID: 17824170 [PubMed - indexed for MEDLINE]5: Related Articles, LinksTian Y, James S, Zuo J, Fritzsch B, Beisel KW.

Conditional and inducible gene recombineering in the mouse inner ear.
Brain Res. 2006 May 26;1091(1):243-54. Epub 2006 Feb 20. Review.
PMID: 16488403 [PubMed - indexed for MEDLINE]6: Related Articles, LinksZenz R, Wagner EF.

Jun signalling in the epidermis: From developmental defects to psoriasis and skin tumors.
Int J Biochem Cell Biol. 2006;38(7):1043-9. Epub 2005 Dec 20. Review.
PMID: 16423552 [PubMed - indexed for MEDLINE]7: Related Articles, LinksKeller C, Capecchi MR.

New genetic tactics to model alveolar rhabdomyosarcoma in the mouse.
Cancer Res. 2005 Sep 1;65(17):7530-2. Review.
PMID: 16140913 [PubMed - indexed for MEDLINE]8: Related Articles, LinksReuter H, Pott C, Goldhaber JI, Henderson SA, Philipson KD, Schwinger RH.

Na(+)--Ca2+ exchange in the regulation of cardiac excitation-contraction coupling.
Cardiovasc Res. 2005 Aug 1;67(2):198-207. Review.
PMID: 15935336 [PubMed - indexed for MEDLINE]9: Related Articles, LinksHaase VH.

The VHL tumor suppressor in development and disease: functional studies in mice by conditional gene targeting.
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PMID: 15908240 [PubMed - indexed for MEDLINE]10: Related Articles, LinksKasper S.

Survey of genetically engineered mouse models for prostate cancer: analyzing the molecular basis of prostate cancer development, progression, and metastasis.
J Cell Biochem. 2005 Feb 1;94(2):279-97. Review.
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Analysis of mouse eye development with chimeras and mosaics.
Int J Dev Biol. 2004;48(8-9):793-804. Review.
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RNAi knock-down mice: an emerging technology for post-genomic functional genetics.
Cytogenet Genome Res. 2004;105(2-4):412-21. Review.
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Estrogen-regulated conditional oncoproteins: tools to address open questions in normal myeloid cell function, normal myeloid differentiation, and the genetic basis of differentiation arrest in myeloid leukemia.
Leuk Lymphoma. 2003 Jul;44(7):1131-9. Review.
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Gene targeting technology and advances in the pathophysiology of inflammation.
Pathology. 2002 Apr;34(2):109-14. Review.
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Genetically engineered mice for studies of stress-related clinical conditions.
J Psychiatr Res. 2002 Mar-Apr;36(2):53-76. Review.
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Genome engineering via homologous recombination in mouse embryonic stem (ES) cells: an amazingly versatile tool for the study of mammalian biology.
An Acad Bras Cienc. 2001 Sep;73(3):365-83. Review. Erratum in: An Acad Bras Cienc 2001 Dec;73(4):577-80.
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Beyond 'knock-out' mice: new perspectives for the programmed modification of the mammalian genome.
Mol Hum Reprod. 1998 Oct;4(10):929-38. Review.
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Transgenic models in renal tubular physiology.
Exp Nephrol. 1998 Sep-Oct;6(5):438-46. Review.
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Genetic ablation in transgenic mice.
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